Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565232 | 0.98 | LMNA (0.52) | LMNAALDH1A1TSHRUSP2PKM | |
| SCHEMBL13565856 | 0.84 | LMNA (0.49) | LMNAALDH1A1TSHRUSP2PKM | |
| SCHEMBL13565356 | 0.82 | LMNA (0.52) | LMNAALDH1A1TSHRUSP2PKM | |
| SCHEMBL13564990 | 0.81 | GAA (0.47) | LMNAALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL11936009 | 0.80 | USP2 (0.49) | LMNAALDH1A1TSHRUSP2L3MBTL1 | |
| SCHEMBL10116370 | 0.80 | MEN1 (0.57) | ALDH1A1PKMMAPTSMN1; SMN2NPC1 | |
| SCHEMBL13565011 | 0.80 | CA1 (0.53) | LMNAALDH1A1USP2L3MBTL1HTT | |
| SCHEMBL13565670 | 0.79 | USP2 (0.43) | LMNAALDH1A1TSHRUSP2PKM | |
| SCHEMBL11935323 | 0.78 | GAA (0.45) | LMNAALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL11936018 | 0.78 | USP2 (0.52) | LMNAALDH1A1TSHRUSP2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |