Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090306 | 1.00 | CYP2C19 (0.45) | CYP2C19NCF1OPRK1ADRA2ANPY5R | |
| SCHEMBL13564811 | 0.85 | CYP2C19 (0.45) | CYP2C19NCF1OPRK1ADRA2ANPY5R | |
| SCHEMBL17090089 | 0.84 | NPY5R (0.44) | ADRA2ANPY5RMCHR1KMT2AMEN1 | |
| SCHEMBL13565529 | 0.84 | NPY5R (0.44) | ADRA2ANPY5RMCHR1KMT2AMEN1 | |
| SCHEMBL13203795 | 0.80 | NPY5R (0.49) | OPRK1NPY5RL3MBTL1KMT2AMEN1 | |
| SCHEMBL10133717 | 0.80 | NPY5R (0.49) | OPRK1NPY5RL3MBTL1KMT2AMEN1 | |
| SCHEMBL13565406 | 0.80 | CRHR1 (0.55) | OPRK1L3MBTL1KMT2AMEN1HTT | |
| SCHEMBL17090303 | 0.80 | CRHR1 (0.55) | OPRK1L3MBTL1KMT2AMEN1HTT | |
| SCHEMBL13438708 | 0.79 | CYP2C19 (0.53) | CYP2C19NCF1OPRK1CD38L3MBTL1 | |
| SCHEMBL11934836 | 0.79 | CYP2C19 (0.53) | CYP2C19NCF1OPRK1CD38L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |