Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13566071 | 0.90 | ALDH1A1 (0.48) | CA9CA1CA12CA2GRIA1 | |
| SCHEMBL13566016 | 0.88 | GRIA1 (0.40) | CA9CA1CA12CA2GRIA1 | |
| SCHEMBL11935357 | 0.88 | GRIA1 (0.41) | GRIA1POLBALDH1A1HPGDMAPT | |
| SCHEMBL10115535 | 0.87 | ALDH1A1 (0.43) | POLBALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL13565962 | 0.87 | CA9 (0.42) | CA9CA1CA12CA2POLB | |
| SCHEMBL13566094 | 0.85 | GRIA1 (0.37) | CA9CA1CA12CA2GRIA1 | |
| SCHEMBL13565723 | 0.85 | GRIA1 (0.40) | CA9CA1CA12CA2GRIA1 | |
| SCHEMBL11935719 | 0.82 | ALDH1A1 (0.40) | CA9CA1CA12CA2POLB | |
| SCHEMBL17090278 | 0.82 | GRIA1 (0.46) | GRIA1POLBALDH1A1HPGDNPY5R | |
| SCHEMBL13565051 | 0.81 | GRIA1 (0.54) | CA1CA2GRIA1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |