Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565993 | 0.86 | PPARA (0.55) | PPARAFFAR1ALDH1A1 | |
| SCHEMBL12649969 | 0.84 | CDK1 (0.58) | FFAR1FFAR4CDK1CCNB1CCNA2 | |
| SCHEMBL11935295 | 0.84 | LMNA (0.47) | FFAR1FFAR4CDK1CCNB1CCNA2 | |
| SCHEMBL13565835 | 0.84 | MAPT (0.47) | PPARAFFAR1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13565070 | 0.82 | PPARA (0.50) | PPARAFFAR1MAPTLMNASMN1; SMN2 | |
| SCHEMBL10055021 | 0.81 | NPSR1 (0.55) | PPARAFFAR1FFAR4MAPTLMNA | |
| SCHEMBL13565502 | 0.81 | CTPS1 (0.45) | MAPTLMNAALDH1A1 | |
| SCHEMBL1391597 | 0.81 | IDH2 (0.48) | PPARAMAPTLMNAMEN1KMT2A | |
| SCHEMBL13565062 | 0.81 | PPARA (0.44) | PPARAFFAR4MAPTLMNACYP3A4 | |
| SCHEMBL13565602 | 0.81 | SLC22A12 (0.44) | PPARAFFAR4LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |