Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 19/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13564790 | 0.84 | NPY5R (0.47) | NPY5RCYP2D6 | |
| SCHEMBL10113479 | 0.81 | ALDH1A1 (0.50) | NPC1RAB9A | |
| SCHEMBL11935072 | 0.81 | NPY5R (0.67) | NPY5RCYP2D6NPC1RAB9A | |
| SCHEMBL17089977 | 0.78 | ALDH1A1 (0.46) | NPY5RNPC1RAB9A | |
| SCHEMBL24590345 | 0.76 | RAB9A (0.57) | NPY5RNPC1RAB9A | |
| SCHEMBL13565525 | 0.76 | NPY5R (0.54) | NPY5RCYP2D6 | |
| SCHEMBL11934938 | 0.75 | RAB9A (0.47) | NPY5RNPC1RAB9A | |
| SCHEMBL4099165 | 0.75 | RAB9A (0.59) | NPY5RNPC1RAB9A | |
| SCHEMBL11935614 | 0.70 | ALDH1A1 (0.46) | NPY5RCYP2D6 | |
| SCHEMBL13565821 | 0.70 | ALDH1A1 (0.49) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |