Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.35 |
| ▸ | CHRNG | P07510 | 1/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CHRND | Q07001 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13567917 | 0.92 | ALDH1A1 (0.34) | ALDH1A1SLC6A2SLC6A3NPSR1KMT2A | |
| SCHEMBL3834344 | 0.87 | NPSR1 (0.42) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL3873239 | 0.87 | NPSR1 (0.42) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL4204488 | 0.87 | NPSR1 (0.42) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL1508961 | 0.87 | NPSR1 (0.42) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL3834348 | 0.87 | NPSR1 (0.42) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL1508787 | 0.85 | NPSR1 (0.36) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL13567931 | 0.85 | NPSR1 (0.36) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL13567955 | 0.83 | CHRNA1 (0.38) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL13567957 | 0.83 | CHRNA1 (0.38) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312310-A1 | Imidazothiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-12-17 | — | — | US | disclosed |
| US-20090312310-A1 | Imidazothiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312310-A1 | Imidazothiazole derivatives | TP53, MDM2, TP53BP1 | ALDH1A1 1990/4885CHRNA1 4540/4885CHRNG 4825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.