Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | PPARG | P37231 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.55 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675536 | 0.89 | HDAC6 (0.77) | HDAC6KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL19029193 | 0.86 | HDAC6 (1.00) | HDAC6KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL2242975 | 0.81 | ALDH1A1 (0.71) | HDAC6KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL23513405 | 0.79 | SMN1; SMN2 (0.68) | HDAC6KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL1675359 | 0.79 | HDAC6 (0.63) | HDAC6KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL19029328 | 0.79 | HDAC6 (1.00) | HDAC6KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL2246803 | 0.79 | MAPT (0.58) | HDAC6KDM4EHPGDTP53MAPT | |
| SCHEMBL15223796 | 0.78 | RAB9A (0.67) | HDAC6KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL2246261 | 0.78 | MAPT (0.67) | HDAC6KDM4EHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL2247861 | 0.78 | RAB9A (0.66) | HDAC6KDM4EHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151546-A2 | METHODS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |