Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13569365 | 0.99 | LMNA (0.44) | LMNAALDH1A1TP53RAB9APOLB | |
| SCHEMBL13570012 | 0.94 | HDAC1 (0.42) | LMNAALDH1A1TP53RAB9APOLB | |
| SCHEMBL13569943 | 0.94 | LMNA (0.45) | LMNAALDH1A1TP53RAB9APOLB | |
| SCHEMBL4228729 | 0.93 | ALDH1A1 (0.47) | LMNAALDH1A1TP53RAB9APOLB | |
| SCHEMBL2386861 | 0.92 | ALDH1A1 (0.47) | LMNAALDH1A1TP53RAB9APOLB | |
| SCHEMBL13569999 | 0.90 | HDAC1 (0.43) | LMNAALDH1A1HDAC1HSD17B10TSHR | |
| SCHEMBL4232494 | 0.90 | ALDH1A1 (0.49) | LMNAALDH1A1TP53RAB9APOLB | |
| SCHEMBL13585891 | 0.90 | NAMPT (0.40) | LMNAALDH1A1HDAC1KDM4EHPGD | |
| SCHEMBL13569946 | 0.89 | KDM4E (0.44) | ALDH1A1RAB9APOLBHDAC1KDM4E | |
| SCHEMBL13569958 | 0.88 | LMNA (0.49) | LMNAALDH1A1TP53HDAC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |