Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.43 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13336192 | 0.91 | MAP4K1 (0.43) | MAP4K1MAP4K3IRAK1TTKJAK2 | |
| SCHEMBL13573976 | 0.90 | MAP4K1 (0.44) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL13573972 | 0.90 | MAP4K1 (0.44) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL13336207 | 0.89 | MAP4K1 (0.41) | MAP4K1MAP4K3IRAK1TTKJAK2 | |
| SCHEMBL13574019 | 0.86 | GRM2 (0.42) | MAP4K1MAP4K3TTKFGFR1FGFR2 | |
| SCHEMBL13574009 | 0.84 | FGFR1 (0.41) | MAP4K1MAP4K3FGFR1FGFR2FGFR4 | |
| SCHEMBL13574101 | 0.81 | TTK (0.44) | MAP4K1MAP4K3TTKFGFR1FGFR2 | |
| SCHEMBL13574110 | 0.81 | MAP4K1 (0.46) | MAP4K1JAK2JAK3KDRJUN | |
| SCHEMBL13336028 | 0.80 | MAP4K1 (0.43) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL13362896 | 0.80 | MAP4K1 (0.43) | MAP4K1MAP4K3JUNMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |