Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.42 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 9/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13362797 | 0.92 | TTK (0.44) | TTKMAP4K1MAP4K3GRM2FGFR1 | |
| SCHEMBL13336142 | 0.92 | TTK (0.44) | TTKMAP4K1MAP4K3GRM2FGFR1 | |
| SCHEMBL13336104 | 0.90 | TTK (0.43) | TTKMAP4K1MAP4K3GRM2FGFR1 | |
| SCHEMBL13573976 | 0.84 | MAP4K1 (0.44) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL13573972 | 0.84 | MAP4K1 (0.44) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL13336174 | 0.82 | GRM2 (0.45) | TTKMAP4K1MAP4K3GRM2FGFR1 | |
| SCHEMBL13574019 | 0.81 | GRM2 (0.42) | TTKMAP4K1MAP4K3GRM2FGFR1 | |
| SCHEMBL13574033 | 0.81 | MAP4K1 (0.43) | TTKMAP4K1MAP4K3FGFR1FGFR2 | |
| SCHEMBL13336181 | 0.80 | GRM2 (0.43) | TTKMAP4K1MAP4K3GRM2JUN | |
| SCHEMBL13574110 | 0.79 | MAP4K1 (0.46) | MAP4K1KDRJUNMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |