Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133703 | 0.91 | MET (0.53) | MET | |
| SCHEMBL12730511 | 0.89 | MET (0.51) | MET | |
| SCHEMBL12730478 | 0.86 | MET (0.40) | MET | |
| SCHEMBL12224232 | 0.84 | MET (0.39) | MET | |
| SCHEMBL13575024 | 0.83 | MET (0.43) | MET | |
| SCHEMBL2456670 | 0.82 | MET (0.36) | MET | |
| SCHEMBL12245549 | 0.82 | BRAF (0.37) | MET | |
| SCHEMBL13970433 | 0.80 | MET (0.55) | MET | |
| SCHEMBL12547601 | 0.76 | PRMT6 (0.42) | MET | |
| SCHEMBL1133813 | 0.76 | MET (0.54) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152920-A1 | 3-(3-PYRIMIDIN-2-YL-BENZYL)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES AS MET KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2009-12-23 | — | — | WO | disclosed |