Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10211129 | 0.87 | MAPK13 (0.36) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL10212091 | 0.82 | MAPK13 (0.43) | MAPK13MAPK12MAPK11MAPK14CHEK1 | |
| SCHEMBL490432 | 0.80 | HPGD (0.43) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL10169814 | 0.80 | HPGD (0.43) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL490433 | 0.80 | HPGD (0.43) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL10169821 | 0.76 | RIPK1 (0.41) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL490240 | 0.76 | RIPK1 (0.41) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL10211121 | 0.74 | NR3C1 (0.44) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL13575466 | 0.70 | MAPK13 (0.39) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL10332064 | 0.63 | MKNK1 (0.65) | MAPK13MAPK12MAPK11MAPK14HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158380-A1 | CYCLOPENTATHIOPHENE MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KAPPA B ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |