Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CGAS | Q8N884 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21224439 | 0.83 | CA1 (0.41) | SMN1; SMN2KMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL11595205 | 0.81 | CGAS (0.48) | CGASCDK5CDK5R1SMN1; SMN2KMT2A | |
| SCHEMBL1358356 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL22290987 | 0.79 | MAPK1 (0.47) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPC1 | |
| SCHEMBL706986 | 0.78 | L3MBTL1 (0.44) | SMN1; SMN2KMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL14350428 | 0.77 | KMT2A (0.58) | CGASCDK5CDK5R1SMN1; SMN2KMT2A | |
| SCHEMBL28673478 | 0.77 | KDM4E (0.40) | SMN1; SMN2KMT2ANPC1RAB9ALMNA | |
| SCHEMBL13681839 | 0.77 | L3MBTL1 (0.61) | SMN1; SMN2KMT2ANPC1RAB9ALMNA | |
| SCHEMBL28675112 | 0.76 | CYP1A2 (0.42) | SMN1; SMN2KMT2ACYP1A2CYP2C19NPC1 | |
| SCHEMBL9687478 | 0.76 | L3MBTL1 (0.47) | CGASCDK5CDK5R1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481577-B2 | Amide thiazole derivative, preparation method and uses thereof | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2013-07-09 | — | — | US | disclosed |
| EP-2404909-B1 | AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF | TIANJIN INST PHARM RESEARCH (CN) | 2013-05-29 | — | — | EP | disclosed |
| EP-2404909-A1 | AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF | Tianjin Institute Of Pharmaceutical Research (CN) | 2012-01-11 | — | — | EP | disclosed |
| US-20110281922-A1 | AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281922-A1 | AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF | DPP4, DPP3, DPP7 | CGAS 3323/4885CDK5 771/4885CDK5R1 1097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.