SCHEMBL135810

SCHEMBL135810

S=C=Nc1c2ccccc2nc2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
HPGD P15428 4/20 0.47
MAOA P21397 3/20 0.47
HSD17B10 Q99714 3/20 0.47
ADRA2A P08913 2/20 0.47
ADORA3 P0DMS8 2/20 0.47
DRD1 P21728 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
CYP1A2 P05177 2/20 0.47
ABCB11 O95342 1/20 0.47
NR3C1 P04150 1/20 0.47
CYP3A4 P08684 1/20 0.47
ALOX15 P16050 1/20 0.47
ADRA2C P18825 1/20 0.47
SLC6A4 P31645 1/20 0.47
HTR2B P41595 1/20 0.47
CCR2 P41597 1/20 0.47
MIF P14174 1/20 0.46
KDM4E B2RXH2 5/20 0.45
GLA P06280 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29548932 1.00 ALDH1A1 (0.47) ALDH1A1HPGDMAOAHSD17B10ADRA2A
Acridine SCHEMBL2317889 0.91 ALDH1A1 (0.52) ALDH1A1HPGDMAOAHSD17B10ADRA2A
SCHEMBL4580940 0.79 KDM4E (0.45) ALDH1A1HPGDMAOAHSD17B10ADRA2A
SCHEMBL28193792 0.71 ALDH1A1 (0.50) ALDH1A1HPGDMAOAHSD17B10ADRA2A
SCHEMBL2066411 0.71 KDM4E (0.50) ALDH1A1HPGDMAOAHSD17B10ADRA2A
SCHEMBL37656 0.71 ALDH1A1 (0.61) ALDH1A1HPGDMAOAHSD17B10ADRA2A
SCHEMBL3289579 0.71 ALDH1A1 (0.46) ALDH1A1HPGDMAOAHSD17B10ADRA2A
SCHEMBL18396131 0.68 ALDH1A1 (0.52) ALDH1A1HPGDMAOAHSD17B10ADRA2A
SCHEMBL15624393 0.68 KDM4E (0.52) ALDH1A1HPGDMAOAHSD17B10ADRA2A
SCHEMBL18396133 0.68 ALDH1A1 (0.52) ALDH1A1HPGDMAOAHSD17B10ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2068 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103221070-B Shear for stenotic lesion and thrombolytic therapy controls release 哈佛大学校长及研究员协会 2019-07-12 CN claimed
EP-2611466-B1 SHEAR CONTROLLED RELEASE OF THROMBOLYTIC THERAPIES FOR STENOTIC LESIONS HARVARD COLLEGE (US) 2019-06-12 EP claimed
CN-104327043-B A kind of acridine thioether analog derivative and its production and use GUANGXI UNIVERSITY OF CHINESE MEDICINE (CN) 2017-01-04 CN claimed
CN-103221070-A Shear controlled release for stenotic lesions and thrombolytic therapies HARVARD COLLEGE 2013-07-24 CN claimed
EP-2611466-A2 SHEAR CONTROLLED RELEASE FOR STENOTIC LESIONS AND THROMBOLYTIC THERAPIES President and Fellows of Harvard College (US) 2013-07-10 EP claimed
WO-2012074588-A2 SHEAR CONTROLLED RELEASE FOR STENOTIC LESIONS AND THROMBOLYTIC THERAPIES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-06-07 WO claimed
US-8017331-B2 IRE-1α substrates MANNKIND CORPORATION (US) 2011-09-13 US claimed
JP-4723725-B2 2011-07-13 JP claimed
EP-1194768-A4 POLYPEPTIDE FINGERPRINTING METHODS, METABOLIC PROFILING, AND BIOINFORMATICS DATABASE TARGET DISCOVERY INC (US) 2008-03-26 EP claimed
US-20070190659-A1 Method for analyzing n-terminal protein adducts ADDUCT ANALYS AB (SE) 2007-08-16 US claimed
WO-2005035794-A2 DETECTION OF PRRSV TETRACORE, INC. (US) 2005-04-21 WO claimed
US-20030119069-A1 Labeling of protein samples TARGET DISCOVERY, INC. 2003-06-26 US claimed
EP-1194768-A1 POLYPEPTIDE FINGERPRINTING METHODS, METABOLIC PROFILING, AND BIOINFORMATICS DATABASE Target Discovery, Inc. (US) 2002-04-10 EP claimed
WO-2000063683-A1 POLYPEPTIDE FINGERPRINTING METHODS, METABOLIC PROFILING, AND BIOINFORMATICS DATABASE TARGET DISCOVERY, INC. (US) 2000-10-26 WO claimed
EP-0270651-B1 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES CALIFORNIA INST OF TECHN (US) 1994-06-15 EP claimed
US-5280015-A 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1994-01-18 US claimed
US-5118802-A DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1992-06-02 US claimed
EP-0270651-A4 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. CALIFORNIA INST OF TECHN (US) 1989-03-29 EP claimed
EP-0270651-A1 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. CALIFORNIA INST OF TECHN (US) 1988-06-15 EP claimed
WO-1988000201-A1 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES CALIFORNIA INSTITUTE OF TECHNOLOGY, INC. (US) 1988-01-14 WO claimed