Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALB | P02768 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7722823 | 0.86 | GABRA1 (0.70) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL3142613 | 0.86 | GABRA1 (0.70) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11464920 | 0.86 | ADRA1A (0.61) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL21272249 | 0.83 | CHRM1 (0.58) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL21272128 | 0.83 | CHRM1 (0.58) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11391896 | 0.83 | KMT2A (0.73) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL28926377 | 0.81 | ADRA1A (0.53) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL20473304 | 0.81 | ADRA1A (0.53) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL28926380 | 0.81 | ADRA1A (0.53) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11389506 | 0.81 | GABRA1 (0.61) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273012-B2 | Facile preparation of 4-substituted quinazolines and related heterocycles | UNIVERSITY OF HOUSTON SYSTEM (US) | 2016-03-01 | — | — | US | disclosed |
| US-20120283436-A1 | FACILE PREPARATION OF 4-SUBSTITUTED QUINAZOLINES AND RELATED HETEROCYCLES | THE UNIVERSITY OF HOUSTON (US) | 2012-11-08 | — | — | US | disclosed |
| WO-2012151141-A2 | A FACILE PREPARATION OF 4-SUBSTITUTED QUINAZOLINES AND RELATED HETEROCYCLES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2012-11-08 | — | — | WO | disclosed |