Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.62 |
| ▸ | KDR | P35968 | 14/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587175 | 0.90 | MET (0.62) | METKDRCYP3A4CYP2D6AURKA | |
| SCHEMBL13587143 | 0.88 | MET (0.67) | METKDRCYP3A4CYP2D6AURKA | |
| SCHEMBL13587147 | 0.85 | MET (0.64) | METKDRAURKALCKTEK | |
| SCHEMBL4370355 | 0.85 | MET (0.73) | METKDRCYP3A4CYP2D6AURKA | |
| SCHEMBL13587154 | 0.83 | NPC1 (0.68) | METKDRCYP3A4CYP2D6AURKA | |
| SCHEMBL4367742 | 0.83 | MET (0.71) | METKDRCYP3A4CYP2D6AURKA | |
| SCHEMBL4379209 | 0.83 | MET (0.70) | METKDRMEN1NPC1RAB9A | |
| SCHEMBL4373514 | 0.83 | MET (0.70) | METKDRCYP3A4CYP2D6AURKA | |
| SCHEMBL13587164 | 0.83 | MET (0.65) | METKDRCYP3A4AURKALCK | |
| SCHEMBL4370568 | 0.83 | MET (0.70) | METKDRCYP3A4CYP2D6AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |