Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.65 |
| ▸ | AXL | P30530 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 11/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587150 | 0.87 | NPC1 (0.72) | METAXLNPC1RAB9AMAPT | |
| SCHEMBL13587149 | 0.86 | MET (0.65) | METAXLNPC1RAB9AMAPT | |
| SCHEMBL13587161 | 0.86 | MET (0.65) | METAXLNPC1RAB9AMAPT | |
| SCHEMBL13587165 | 0.86 | MET (0.67) | METAXLNPC1RAB9AMAPT | |
| SCHEMBL4378894 | 0.85 | MET (0.68) | METAXLNPC1RAB9AKMT2A | |
| SCHEMBL4379209 | 0.85 | MET (0.70) | METAXLNPC1RAB9AKMT2A | |
| SCHEMBL13587168 | 0.85 | MET (0.65) | METAXLNPC1RAB9AMAPT | |
| SCHEMBL4372566 | 0.84 | MET (0.67) | METAXLNPC1RAB9AKMT2A | |
| SCHEMBL13587155 | 0.84 | MET (0.67) | METAXLNPC1RAB9AMAPT | |
| SCHEMBL13587143 | 0.84 | MET (0.67) | METAXLNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |