Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 16/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4157438 | 0.87 | P2RX7 (0.49) | P2RX7POLBMEN1USP2KMT2A | |
| SCHEMBL4147936 | 0.82 | P2RX7 (0.51) | P2RX7POLB | |
| SCHEMBL13243884 | 0.80 | P2RX7 (0.54) | P2RX7 | |
| SCHEMBL4154127 | 0.79 | P2RX7 (0.76) | P2RX7KMT2A | |
| SCHEMBL4132630 | 0.79 | P2RX7 (0.53) | P2RX7POLBMEN1KMT2A | |
| SCHEMBL4147036 | 0.79 | P2RX7 (0.49) | P2RX7POLBKMT2ASHMT2 | |
| SCHEMBL4145612 | 0.78 | P2RX7 (0.49) | P2RX7POLBKMT2A | |
| SCHEMBL13587418 | 0.78 | P2RX7 (0.60) | P2RX7MEN1USP2KMT2A | |
| SCHEMBL4142159 | 0.78 | P2RX7 (0.52) | P2RX7POLB | |
| SCHEMBL13243898 | 0.78 | P2RX7 (0.62) | P2RX7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298825-A1 | Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof | RENOVIS, INC. | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298825-A1 | Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX1 | P2RX7 1/4885POLB 3609/4885MEN1 4837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.