Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.65 |
| ▸ | RECQL | P46063 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.65 |
| ▸ | BACE1 | P56817 | 3/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767910 | 0.91 | SLC7A5 (0.77) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| SCHEMBL338068 | 0.91 | SLC7A5 (0.77) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| SCHEMBL29508389 | 0.91 | SLC7A5 (0.77) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| Levodopa SCHEMBL5494247 | 0.90 | SLC7A5 (0.82) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| Levodopa SCHEMBL5494243 | 0.90 | SLC7A5 (0.82) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| Levodopa SCHEMBL1491625 | 0.90 | SLC7A5 (0.82) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| Levodopa SCHEMBL1491628 | 0.90 | SLC7A5 (0.82) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| Levodopa SCHEMBL28992922 | 0.88 | SLC7A5 (0.79) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| SCHEMBL9924695 | 0.85 | SLC7A5 (0.69) | SLC7A5KDM4EPTGS1RECQLTDP1 | |
| SCHEMBL29364864 | 0.85 | SLC7A5 (0.69) | SLC7A5KDM4EPTGS1RECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318171-B2 | Neurotoxic oligomers | PRANA BIOTECHNOLOGY LIMITED (AU) | 2012-11-27 | — | — | US | disclosed |
| US-20090297538-A1 | NEUROTOXIC OLIGOMERS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2009-12-03 | — | — | US | disclosed |