Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PYGB | P11216 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HK2 | P52789 | 5/20 | 0.48 |
| ▸ | HK1 | P19367 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14000603 | 1.00 | LMNA (0.56) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL29906478 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL15334409 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL28790741 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL15334407 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL24943581 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL15046974 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL18193284 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL17215084 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB | |
| SCHEMBL29574842 | 0.87 | PYGB (0.64) | LMNAKDM4ECYP2D6CYP2C19PYGB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090324489-A1 | Wortmannin conjugates and uses thereof | BETH ISRAEL DEACONESS MEDICAL CENTER | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090324489-A1 | Wortmannin conjugates and uses thereof | PIK3CG, PIK3C3, PIK3CA | LMNA 4663/4885KDM4E 3978/4885CYP2D6 3366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.