Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | HMGCR | P04035 | 2/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.38 |
| ▸ | MYLK | Q15746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596107 | 0.81 | HTT (0.66) | HTTHMGCRPRKCEMYLKMEN1 | |
| SCHEMBL13841098 | 0.81 | CYP3A4 (0.47) | HTTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL29434854 | 0.72 | MGLL (0.49) | HTTESR1ESR2HMGCRRECQL | |
| SCHEMBL29434876 | 0.72 | MGLL (0.49) | HTTESR1ESR2HMGCRRECQL | |
| SCHEMBL17388702 | 0.71 | TAAR1 (0.45) | HTTPRKCEMYLKMEN1KMT2A | |
| SCHEMBL13596109 | 0.70 | CYP3A4 (0.50) | HTTPRKCEKMT2AALDH1A1CYP3A4 | |
| SCHEMBL26688315 | 0.70 | MEN1 (0.47) | HTTHMGCRMEN1KMT2AMAPT | |
| SCHEMBL26688311 | 0.70 | MEN1 (0.47) | HTTHMGCRMEN1KMT2AMAPT | |
| SCHEMBL29063428 | 0.69 | MAPT (0.52) | HTTHMGCRPRKCEMYLKMEN1 | |
| SCHEMBL17307554 | 0.68 | MAPK1 (0.62) | HTTESR1ESR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | NR1I2, NR1I3, NR0B1 | HTT 3905/4885ESR1 412/4885ESR2 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.