Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596107 | 0.86 | HTT (0.66) | CYP3A4HTTKMT2APRKCERAB9A | |
| SCHEMBL11897974 | 0.82 | CYP3A4 (0.50) | CYP3A4HTTTSHRCA9KMT2A | |
| SCHEMBL9417789 | 0.79 | NR1H4 (0.45) | HTTLMNANR1H4SMN1; SMN2 | |
| SCHEMBL30350316 | 0.78 | CYP3A4 (0.69) | CYP3A4HTTTSHRCA9KMT2A | |
| SCHEMBL7457674 | 0.78 | CYP3A4 (0.69) | CYP3A4HTTTSHRCA9KMT2A | |
| SCHEMBL9417859 | 0.78 | ALOX5 (0.46) | CYP3A4HTTTSHRCA9PAX8 | |
| SCHEMBL9417818 | 0.78 | ALOX5 (0.47) | CYP3A4HTTTSHRKMT2ANR1H4 | |
| SCHEMBL20630769 | 0.78 | HTT (0.68) | CYP3A4HTTTSHRCA9KMT2A | |
| SCHEMBL13596110 | 0.77 | PAX8 (0.40) | CYP3A4HTTKMT2APAX8PRKCE | |
| SCHEMBL9417878 | 0.77 | ALOX5 (0.52) | CYP3A4TSHRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | NR1I2, NR1I3, NR0B1 | CYP3A4 157/4885HTT 3905/4885TSHR 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.