Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.35 |
| ▸ | FEN1 | P39748 | 4/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1357846 | 0.96 | HSP90AA1 (0.40) | CHEK1HSP90AA1HSP90AB1ALOX5APFEN1 | |
| SCHEMBL1359797 | 0.95 | CHEK1 (0.38) | CHEK1HSP90AA1HSP90AB1ALOX5APFEN1 | |
| SCHEMBL1360132 | 0.93 | CYP3A4 (0.35) | CHEK1HSP90AA1HSP90AB1ALOX5APFEN1 | |
| SCHEMBL1358259 | 0.91 | KDM1A (0.37) | CHEK1CYP3A4 | |
| SCHEMBL1359468 | 0.89 | MAP4K4 (0.39) | CHEK1PDK2CYP3A4TLR9TLR8 | |
| SCHEMBL1359465 | 0.89 | MAP4K4 (0.39) | CHEK1PDK2CYP3A4TLR9TLR8 | |
| SCHEMBL3144828 | 0.89 | PDK2 (0.36) | CHEK1PDK2CYP3A4GAA | |
| SCHEMBL1359564 | 0.89 | MAP4K4 (0.39) | CHEK1PDK2CYP3A4TLR9TLR8 | |
| SCHEMBL1360760 | 0.89 | HTR2C (0.36) | CHEK1PDK2CYP3A4GAA | |
| SCHEMBL1360205 | 0.89 | KDM1A (0.38) | HSP90AA1HSP90AB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067442-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2011-11-29 | — | — | US | claimed |
| US-20100081658-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | ROCHE PALO ALTO LLC | 2010-04-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081658-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | EIF2AK2, POLR2A, HCCS | CHEK1 1363/4885HSP90AA1 2114/4885HSP90AB1 1378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.