Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 15/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 12/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 12/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 12/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.35 |
| ▸ | DRD2 | P14416 | 9/20 | 0.35 |
| ▸ | DRD4 | P21917 | 8/20 | 0.35 |
| ▸ | DRD3 | P35462 | 8/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL97366 | 0.86 | NMT1 (0.35) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL13602468 | 0.83 | GPR119 (0.39) | — | |
| SCHEMBL99956 | 0.83 | CYP11B1 (0.35) | CYP11B1 | |
| SCHEMBL13598463 | 0.81 | GRIN2B (0.41) | CHRM1KCNH2ALDH1A1NPSR1 | |
| SCHEMBL97390 | 0.79 | CHRM1 (0.38) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL95362 | 0.76 | DRD2 (0.36) | CHRM1DRD2DRD4DRD3KCNH2 | |
| SCHEMBL96366 | 0.74 | HRH3 (0.46) | CA2HRH3ALDH1A1 | |
| SCHEMBL94951 | 0.73 | HRH3 (0.38) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL13598449 | 0.72 | FFAR1 (0.44) | CHRM1CHRM5CHRM3CA2HRH3 | |
| SCHEMBL13598450 | 0.70 | PPARG (0.41) | KCNH2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090326008-A1 | NF-kappa B Inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326008-A1 | NF-kappa B Inhibitor | NFKBIA, NFKB2, IKBKB | CHRM1 2682/4885CHRM2 3353/4885CHRM4 3803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.