Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 7/20 | 0.70 |
| ▸ | TNKS | O95271 | 5/20 | 0.62 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.62 |
| ▸ | PARP1 | P09874 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.62 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | CSK | P41240 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623659 | 0.91 | GUSB (0.75) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL1084872 | 0.85 | GUSB (0.78) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL29740691 | 0.85 | GUSB (0.78) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL16007938 | 0.82 | GUSB (1.00) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL11379676 | 0.80 | GUSB (0.51) | GUSBTNKSTNKS2CYP1A1CYP1B1 | |
| SCHEMBL16017996 | 0.79 | GUSB (0.76) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL16007517 | 0.79 | GUSB (1.00) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL31238611 | 0.79 | GUSB (1.00) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL6695759 | 0.79 | TNKS2 (0.81) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL4494793 | 0.79 | GUSB (0.58) | GUSBTNKSTNKS2PARP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9320815-B2 | Compounds and methods for enzyme-mediated tumor imaging and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-04-26 | — | — | US | disclosed |
| US-8394953-B2 | Compounds and methods for enzyme-mediated tumor imaging and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-03-12 | — | — | US | disclosed |
| US-20090324495-A1 | COMPOUNDS AND METHODS FOR ENZYME-MEDIATED TUMOR IMAGING AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090324495-A1 | COMPOUNDS AND METHODS FOR ENZYME-MEDIATED TUMOR IMAGING AND THERAPY | GAA, RNASE1, GUSB | GUSB 3/4885TNKS 707/4885TNKS2 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.