Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 9/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TNKS | O95271 | 3/20 | 0.62 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.62 |
| ▸ | PARP1 | P09874 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.62 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | C1R | P00736 | 1/20 | 0.58 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740691 | 1.00 | GUSB (0.78) | GUSBKDM4EHPGDTNKSTNKS2 | |
| SCHEMBL16007938 | 0.88 | GUSB (1.00) | GUSBKDM4EHPGDTNKSTNKS2 | |
| SCHEMBL13599387 | 0.85 | GUSB (0.70) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL13604403 | 0.85 | GUSB (0.69) | GUSBKDM4EHPGDTNKSTNKS2 | |
| SCHEMBL23743251 | 0.85 | GUSB (0.72) | GUSBKDM4ETNKSTNKS2PARP1 | |
| SCHEMBL183953 | 0.85 | GUSB (0.59) | GUSBTNKSTNKS2PARP1NPC1 | |
| SCHEMBL183430 | 0.85 | GUSB (0.59) | GUSBTNKSTNKS2PARP1CYP1A1 | |
| SCHEMBL7160589 | 0.85 | GUSB (1.00) | GUSBKDM4EHPGD | |
| SCHEMBL10205334 | 0.85 | GUSB (0.68) | GUSBKDM4EHPGDTNKSTNKS2 | |
| SCHEMBL31238756 | 0.85 | GUSB (1.00) | GUSBKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371731-B1 | Quinazolinone derivatives | SMITH KLINE FRENCH LAB (GB) | 1994-04-20 | — | — | EP | claimed |
| US-5147875-A | 2-(SUBSTITUTED PHENYL)-4-OXO-QUINAZOLINES | SANSHIN KOGYO KABISHIKI KAISHA (JP) | 1992-09-15 | — | — | US | claimed |
| EP-0371731-A2 | Quinazolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-06-06 | — | — | EP | claimed |
| US-20240027346-A1 | DETECTION METHOD | THE UNIVERSITY OF QUEENSLAND (AU) | 2024-01-25 | — | — | US | disclosed |
| CN-109879820-B | Synthetic method of quinazolinone heterocyclic compound | 扬州大学 | 2022-07-19 | — | — | CN | disclosed |
| CN-110272392-B | Transition metal catalyzed C-H coupling for efficiently preparing 2- (4(3H) -quinazolinone) aryl alkyl acetate derivative | 四川大学 | 2022-07-01 | — | — | CN | disclosed |
| US-20170073359-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MOLECULAR PROBES, INC. | 2017-03-16 | — | — | US | disclosed |
| US-20160158390-A1 | Methods for Tumor Diagnosis and Therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-06-09 | — | — | US | disclosed |
| US-20160139135-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | LIFE TECHNOLOGIES CORP (US) | 2016-05-19 | — | — | US | disclosed |
| US-9320815-B2 | Compounds and methods for enzyme-mediated tumor imaging and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-04-26 | — | — | US | disclosed |
| US-8865891-B2 | Optically-detectable enzyme substrates and their method of use | Life Technologies Corporation (US) | 2014-10-21 | — | — | US | disclosed |
| EP-1784393-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2007-05-16 | — | — | EP | disclosed |
| US-20060173018-A1 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2006-08-03 | — | — | US | disclosed |
| WO-2006028904-A9 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2006-06-22 | — | — | WO | disclosed |
| WO-2006028904-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006012577-A2 | QUINAZOLINONE DERIVATIVES USEFUL FOR THE REGULATION OF GLUCOSE HOMEOSTASIS AND FOOD INTAKE | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |
| WO-2004078733-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-16 | — | — | WO | disclosed |
| EP-0371731-B1 | Quinazolinone derivatives | SMITH KLINE FRENCH LAB (GB) | 1994-04-20 | — | — | EP | disclosed |
| US-5147875-A | 2-(SUBSTITUTED PHENYL)-4-OXO-QUINAZOLINES | SANSHIN KOGYO KABISHIKI KAISHA (JP) | 1992-09-15 | — | — | US | disclosed |
| EP-0371731-A2 | Quinazolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240027346-A1 | DETECTION METHOD | NCS1, NGF, ACHE | GUSB 1599/4885KDM4E 3397/4885HPGD 2340/4885 |
| US-20160139135-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MGAM, LCT, GAA | GUSB 22/4885KDM4E 3086/4885HPGD 650/4885 |
| US-20170073359-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MGAM, LCT, GAA | GUSB 22/4885KDM4E 3086/4885HPGD 650/4885 |
| US-20060173018-A1 | Quinazolines useful as modulators of ion channels | KCNQ1, KCNQ2, KCNN3 | GUSB 3959/4885KDM4E 2570/4885HPGD 893/4885 |
| US-20160158390-A1 | Methods for Tumor Diagnosis and Therapy | FOLH1, DNPEP, ENPEP | GUSB 21/4885KDM4E 4072/4885HPGD 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.