Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13597674 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KMT2AHSD17B10TSHRKDM4E | |
| SCHEMBL13601328 | 0.74 | KDM4E (0.63) | ALDH1A1KDM4ELMNAMAPK1POLB | |
| SCHEMBL2731678 | 0.73 | KMT2A (0.54) | ALDH1A1KMT2AHSD17B10TSHRLMNA | |
| SCHEMBL20892712 | 0.71 | MAPK1 (0.68) | KMT2ATSHRLMNASMN1; SMN2MAPK1 | |
| SCHEMBL2731679 | 0.71 | ALDH1A1 (0.57) | ALDH1A1KMT2AHSD17B10TSHRLMNA | |
| SCHEMBL2721346 | 0.70 | ALDH1A1 (0.64) | ALDH1A1KMT2ATSHRKDM4ELMNA | |
| SCHEMBL17232502 | 0.70 | ALDH1A1 (0.67) | ALDH1A1KMT2ATSHRKDM4ELMNA | |
| SCHEMBL13432836 | 0.69 | MAPK1 (0.48) | ALDH1A1KMT2ATSHRKDM4ESMN1; SMN2 | |
| SCHEMBL4580901 | 0.68 | ALDH1A1 (0.49) | ALDH1A1KMT2AHSD17B10TSHRLMNA | |
| SCHEMBL17232496 | 0.68 | ALDH1A1 (0.68) | ALDH1A1KMT2ATSHRKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | GRM5, GRIK5, GRM1 | ALDH1A1 3104/4885KMT2A 887/4885HSD17B10 3322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.