Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | DRD3 | P35462 | 9/20 | 0.55 |
| ▸ | DRD4 | P21917 | 9/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318936 | 0.85 | ALDH1A1 (0.62) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL22418861 | 0.80 | HTT (0.70) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL8111511 | 0.80 | HTT (0.77) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL4319247 | 0.80 | ALDH1A1 (0.72) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL12259121 | 0.78 | ALDH1A1 (1.00) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL13219071 | 0.78 | ALDH1A1 (0.74) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL7501937 | 0.77 | DRD4 (0.83) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL11828367 | 0.76 | ALDH1A1 (0.60) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL11817430 | 0.76 | ALDH1A1 (0.66) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL27880536 | 0.75 | ALDH1A1 (0.61) | ALDH1A1HTTKDM4ELMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | GRM5, GRIK5, GRM1 | ALDH1A1 3104/4885HTT 1727/4885KDM4E 1411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.