Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601625 | 0.84 | TP53 (0.43) | MEN1KMT2ASIGMAR1MAPTSMN1; SMN2 | |
| SCHEMBL1341702 | 0.82 | TSHR (0.43) | MEN1KMT2ASIGMAR1SMN1; SMN2HRH2 | |
| SCHEMBL14839105 | 0.82 | SIGMAR1 (0.41) | MEN1KMT2ASIGMAR1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16528079 | 0.81 | TSHR (0.42) | MEN1KMT2ASIGMAR1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4123503 | 0.81 | TSHR (0.42) | MEN1KMT2ASIGMAR1MAPTSMN1; SMN2 | |
| SCHEMBL18138091 | 0.81 | TSHR (0.42) | MEN1KMT2ASIGMAR1HRH2HRH1 | |
| SCHEMBL13601437 | 0.81 | POLB (0.48) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12773999 | 0.78 | SMN1; SMN2 (0.40) | KMT2AMAPTSMN1; SMN2ALDH1A1KDM4E | |
| Ethyl Propionate SCHEMBL11668791 | 0.78 | TSHR (0.40) | MEN1KMT2ASIGMAR1SMN1; SMN2HRH2 | |
| SCHEMBL25523506 | 0.77 | HRH2 (0.38) | MEN1KMT2ASIGMAR1SMN1; SMN2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |