Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12773999 | 0.86 | SMN1; SMN2 (0.40) | POLBHTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13601361 | 0.85 | MAPT (0.38) | POLBHTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13601625 | 0.83 | TP53 (0.43) | SMN1; SMN2KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL13601396 | 0.83 | POLB (0.54) | POLBHTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL27976667 | 0.82 | POLB (0.57) | POLBHTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL12774126 | 0.82 | TP53 (0.42) | SMN1; SMN2KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL13601525 | 0.81 | MEN1 (0.38) | POLBSMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL12881444 | 0.80 | TP53 (0.42) | SMN1; SMN2KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL13601415 | 0.79 | POLB (0.48) | POLBHTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL12842063 | 0.79 | GNAI3 (0.41) | SMN1; SMN2MAPTLMNAKCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |