Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601637 | 0.93 | HRH3 (0.54) | LMNAPOLBTSHRALDH1A1HRH3 | |
| SCHEMBL12881504 | 0.88 | LMNA (0.52) | LMNAPOLBTSHRALDH1A1HRH3 | |
| SCHEMBL13601670 | 0.85 | TSHR (0.58) | LMNAPOLBTSHRALDH1A1HRH3 | |
| SCHEMBL12881512 | 0.84 | LMNA (0.49) | LMNAPOLBTSHRALDH1A1HRH3 | |
| SCHEMBL8262848 | 0.82 | HRH3 (0.50) | LMNAPOLBTSHRALDH1A1HRH3 | |
| SCHEMBL12881519 | 0.82 | TSHR (0.49) | LMNAPOLBTSHRALDH1A1HRH3 | |
| SCHEMBL12881500 | 0.81 | LMNA (0.50) | LMNAPOLBTSHRALDH1A1HRH3 | |
| SCHEMBL2606050 | 0.80 | NPC1 (0.67) | LMNAPOLBTSHRALDH1A1NPC1 | |
| SCHEMBL13601626 | 0.79 | NPC1 (0.57) | LMNAPOLBTSHRALDH1A1NPC1 | |
| SCHEMBL13601424 | 0.79 | HRH3 (0.53) | LMNAPOLBALDH1A1HRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |