Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601672 | 0.92 | TSHR (0.56) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL12881504 | 0.89 | LMNA (0.52) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL12881512 | 0.88 | LMNA (0.49) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL12881519 | 0.88 | TSHR (0.49) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL13601635 | 0.85 | LMNA (0.55) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL12881500 | 0.81 | LMNA (0.50) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL12881508 | 0.81 | LMNA (0.47) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL12881528 | 0.81 | LMNA (0.47) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL13239918 | 0.81 | ALDH1A1 (0.57) | TSHRLMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL501897 | 0.79 | ALDH1A1 (0.58) | TSHRLMNAPOLBALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |