Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601772 | 1.00 | GAA (0.43) | GAAKDM4EPKMHRH3USP2 | |
| SCHEMBL13601750 | 0.92 | ATM (0.44) | GAAKDM4EPKMTDP1ALDH1A1 | |
| SCHEMBL13601771 | 0.92 | ATM (0.44) | GAAKDM4EPKMTDP1ALDH1A1 | |
| SCHEMBL7262161 | 0.84 | FKBP1A (0.46) | — | |
| SCHEMBL12881533 | 0.83 | HRH3 (0.39) | GAAKDM4EPKMHRH3USP2 | |
| SCHEMBL7258683 | 0.80 | FKBP1A (0.44) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL13601763 | 0.80 | FKBP1A (0.44) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL13601742 | 0.80 | FKBP1A (0.44) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL12881553 | 0.79 | GAA (0.38) | GAAKDM4EPKMHRH3EPHX2 | |
| SCHEMBL26844154 | 0.79 | EPHX2 (0.51) | GAAKDM4EPKMHRH3USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |