Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2619374 | 0.79 | LMNA (0.49) | TSHRHPGDSMN1; SMN2PARP1 | |
| SCHEMBL2792782 | 0.78 | NPC1 (0.59) | TSHRHPGDHTTSMN1; SMN2CA2 | |
| SCHEMBL17664589 | 0.77 | HDAC8 (0.59) | HDAC2HDAC8HDAC6TSHRHPGD | |
| SCHEMBL250247 | 0.77 | HDAC6 (0.80) | HDAC2HDAC8HDAC6TSHRHPGD | |
| SCHEMBL4444258 | 0.76 | TSHR (0.54) | TSHRHPGDSMN1; SMN2CA2PARP1 | |
| SCHEMBL12897318 | 0.75 | HDAC2 (0.45) | HDAC2HDAC8HDAC6TSHRHPGD | |
| SCHEMBL12385477 | 0.75 | TSHR (0.46) | TSHRSMN1; SMN2PARP1 | |
| SCHEMBL10283170 | 0.73 | HDAC8 (0.69) | HDAC2HDAC8HDAC6TSHRHPGD | |
| SCHEMBL23995263 | 0.73 | PLK1 (0.50) | HDAC2HDAC8HDAC6TSHRHPGD | |
| SCHEMBL23269700 | 0.73 | HDAC8 (0.61) | HDAC2HDAC8HDAC6TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629468-B2 | Neuroprotectants, analgesics or anticonvulsants | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-08 | — | — | US | disclosed |