Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.46 |
| ▸ | KLK7 | P49862 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1360264 | 1.00 | PDE4B (0.56) | PDE4BBACE1BACE2KLK5KLK7 | |
| SCHEMBL7496914 | 0.92 | PDE4B (0.55) | PDE4BBACE1BACE2KLK5KLK7 | |
| SCHEMBL30060223 | 0.92 | PDE4B (0.59) | PDE4BBACE1BACE2KMT2AL3MBTL1 | |
| SCHEMBL7498881 | 0.92 | PDE4B (0.59) | PDE4BBACE1BACE2KMT2AL3MBTL1 | |
| SCHEMBL28568769 | 0.91 | PDE4B (0.55) | PDE4BBACE1BACE2KLK5KLK7 | |
| SCHEMBL28568774 | 0.91 | PDE4B (0.55) | PDE4BBACE1BACE2KLK5KLK7 | |
| SCHEMBL2518065 | 0.91 | PDE4B (0.55) | PDE4BBACE1BACE2KLK5KLK7 | |
| SCHEMBL744418 | 0.90 | PDE4B (0.52) | PDE4BBACE1BACE2KLK5KLK7 | |
| SCHEMBL1360488 | 0.90 | PDE4B (0.52) | PDE4BBACE1BACE2KLK5KLK7 | |
| SCHEMBL23938191 | 0.89 | PDE4B (0.54) | PDE4BKLK5KLK7KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214807-A1 | COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-08-23 | — | — | US | disclosed |
| US-8067457-B2 | Compounds useful as antagonists of CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090197884-A1 | Compounds Useful as Antagonists of CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214807-A1 | COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2 | CCR2, CCR1, CXCR3 | PDE4B 2341/4885BACE1 3593/4885BACE2 4346/4885 |
| US-20090197884-A1 | Compounds Useful as Antagonists of CCR2 | CCR2, CCR1, CXCR3 | PDE4B 2341/4885BACE1 3593/4885BACE2 4346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.