Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mk-0773. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mk-0773 SCHEMBL13935743 | 1.00 | AR (0.81) | ARSRD5A2 | |
| Mk-0773 SCHEMBL4169174 | 1.00 | AR (0.81) | ARSRD5A2 | |
| Mk-0773 SCHEMBL4169171 | 1.00 | AR (0.81) | ARSRD5A2 | |
| SCHEMBL4188008 | 0.90 | AR (0.81) | ARSRD5A2 | |
| SCHEMBL4188011 | 0.90 | AR (0.81) | ARSRD5A2 | |
| Mk-0773 SCHEMBL14387329 | 0.90 | AR (1.00) | ARSRD5A2 | |
| Mk-0773 SCHEMBL29516628 | 0.90 | AR (1.00) | ARSRD5A2 | |
| Mk-0773 SCHEMBL14355641 | 0.90 | AR (1.00) | ARSRD5A2 | |
| SCHEMBL4990703 | 0.86 | AR (0.64) | ARSRD5A2 | |
| SCHEMBL4990696 | 0.86 | AR (0.64) | ARSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625920-B2 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625920-B2 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-20090082320-A1 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators | MERCK SHARP & DOHME CORP. | 2009-03-26 | — | — | US | disclosed |
| US-20090082320-A1 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators | MERCK SHARP & DOHME CORP. | 2009-03-26 | — | — | US | disclosed |
| US-7186838-B2 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2007-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082320-A1 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators | FSHR, AR, NR5A1 | AR 2/4885SRD5A2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.