Mk-0773

SCHEMBL14355641

CN1C(=O)C(F)=C[C@]2(C)C3CC[C@]4(C)[C@@H](C(=O)NCc5nc6ncccc6[nH]5)CC[C@H]4[C@@H]3CC[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Known targets — ChEMBL curated mechanism

The experimentally established mechanism targets of Mk-0773. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	AR known ✓	P10275	3/20	1.00

▸	SRD5A2	P31213	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Mk-0773 SCHEMBL14387329	1.00	AR (1.00)	ARSRD5A2
Mk-0773 SCHEMBL29516628	1.00	AR (1.00)	ARSRD5A2
Mk-0773 SCHEMBL13935743	0.90	AR (0.81)	ARSRD5A2
Mk-0773 SCHEMBL4169171	0.90	AR (0.81)	ARSRD5A2
Mk-0773 SCHEMBL13604131	0.90	AR (0.81)	ARSRD5A2
Mk-0773 SCHEMBL4169174	0.90	AR (0.81)	ARSRD5A2
SCHEMBL4188011	0.89	AR (0.81)	ARSRD5A2
SCHEMBL4188008	0.89	AR (0.81)	ARSRD5A2
SCHEMBL4187544	0.84	AR (0.73)	ARSRD5A2
SCHEMBL4187547	0.84	AR (0.73)	ARSRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7301026-B2	Process for making fluorinated 4-azasteroid derivatives	MERCK & CO., INC (US)	2007-11-27	—	—	US	disclosed
US-7301026-B2	Process for making fluorinated 4-azasteroid derivatives	MERCK & CO., INC (US)	2007-11-27	—	—	US	disclosed