Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.59 |
| ▸ | PGR | P06401 | 4/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.59 |
| ▸ | AR | P10275 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11961969 | 0.93 | NR3C1 (0.55) | NR3C1PGRESR1ARHTT | |
| SCHEMBL14196983 | 0.92 | NR3C1 (0.64) | NR3C1PGRESR1ARHTT | |
| SCHEMBL14197060 | 0.89 | NR3C1 (0.62) | NR3C1PGRESR1ARAOC3 | |
| SCHEMBL12864644 | 0.88 | NR3C1 (0.61) | NR3C1PGRESR1ARHTT | |
| SCHEMBL12864136 | 0.87 | NR3C1 (0.60) | NR3C1PGRESR1ARHTT | |
| SCHEMBL12864339 | 0.87 | NR3C1 (0.62) | NR3C1PGRESR1ARHTT | |
| SCHEMBL12863999 | 0.86 | NR3C1 (0.62) | NR3C1PGRESR1ARMEN1 | |
| SCHEMBL12864129 | 0.86 | NR3C1 (0.61) | NR3C1PGRESR1ARHTT | |
| SCHEMBL12864144 | 0.86 | NR3C1 (0.61) | NR3C1PGRESR1ARHTT | |
| SCHEMBL12864479 | 0.86 | NR3C1 (0.61) | NR3C1PGRESR1ARHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625921-B2 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625921-B2 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-01 | — | — | US | disclosed |