Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 16/20 | 0.50 |
| ▸ | PGR | P06401 | 4/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | ZNF207 | O43670 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13611419 | 0.92 | NR3C1 (0.49) | NR3C1PGRESR1ARALDH1A1 | |
| SCHEMBL11961986 | 0.86 | NR3C1 (0.51) | NR3C1PGRESR1AR | |
| SCHEMBL13604148 | 0.84 | NR3C1 (0.49) | NR3C1PGRESR1AR | |
| SCHEMBL13604147 | 0.81 | NR3C1 (0.59) | NR3C1PGRESR1AR | |
| SCHEMBL11961415 | 0.80 | NR3C1 (0.48) | NR3C1PGRESR1ARALDH1A1 | |
| SCHEMBL14196989 | 0.77 | NR3C1 (0.55) | NR3C1PGRESR1ARZNF207 | |
| SCHEMBL11961113 | 0.77 | NR3C1 (0.55) | NR3C1PGRESR1ARALDH1A1 | |
| SCHEMBL11961002 | 0.75 | NR3C1 (0.50) | NR3C1PGRESR1AR | |
| SCHEMBL11961969 | 0.75 | NR3C1 (0.55) | NR3C1PGRESR1AR | |
| SCHEMBL12306770 | 0.73 | NR3C1 (0.49) | NR3C1PGRESR1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625921-B2 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625921-B2 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-01 | — | — | US | disclosed |