Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.74 |
| ▸ | CASP3 | P42574 | 4/20 | 0.64 |
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.57 |
| ▸ | KAT2A | Q92830 | 3/20 | 0.55 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | G6PD | P11413 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19726955 | 0.86 | HDAC3 (0.79) | HDAC3HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL8230178 | 0.85 | HDAC1 (1.00) | HDAC3HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL13606231 | 0.82 | HDAC3 (0.72) | HDAC3HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL8222491 | 0.81 | CASP3 (0.75) | HDAC3HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL13606220 | 0.80 | KAT2A (0.69) | CASP3KAT2AKAT2BG6PD | |
| SCHEMBL17515279 | 0.78 | CASP3 (1.00) | HDAC3HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL17515278 | 0.76 | CASP3 (0.77) | HDAC3HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL79203 | 0.76 | CASP3 (1.00) | HDAC3HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL18872061 | 0.75 | CASP3 (0.79) | HDAC3HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL12938895 | 0.75 | HDAC6 (0.70) | HDAC3HDAC1HDAC8HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312377-A1 | DERIVATIVES OF BENZO[D]ISOTHIAZOLES AS HISTONES DEACETYLASE INHIBITORS | UNIVERSIDAD DE GRANADA (ES) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312377-A1 | DERIVATIVES OF BENZO[D]ISOTHIAZOLES AS HISTONES DEACETYLASE INHIBITORS | HDAC1, HDAC2, HDAC3 | HDAC3 3/4885HDAC1 1/4885HDAC8 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.