Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ME2 | P23368 | 1/20 | 0.51 |
| ▸ | ME1 | P48163 | 1/20 | 0.51 |
| ▸ | ME3 | Q16798 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14372233 | 0.82 | KDM4E (0.60) | KDM4EMAPTKMT2AL3MBTL1MAPK1 | |
| SCHEMBL13984146 | 0.79 | KDM4E (0.67) | KDM4EMAPTKMT2AL3MBTL1MAPK1 | |
| SCHEMBL26758591 | 0.76 | MAPT (0.84) | KDM4EMAPTMAPK1CYP2C9CYP2C19 | |
| SCHEMBL12994627 | 0.75 | CA12 (0.76) | KDM4EMAPTKMT2AMAPK1CYP2C9 | |
| SCHEMBL22601218 | 0.74 | MAPT (0.76) | KDM4EMAPTMAPK1CYP2C9CYP2C19 | |
| SCHEMBL5060746 | 0.73 | MAPT (0.56) | KDM4EMAPTKMT2AL3MBTL1MAPK1 | |
| SCHEMBL25263692 | 0.72 | CA12 (0.59) | KDM4EMAPTCYP2C19TP53LMNA | |
| SCHEMBL28431287 | 0.72 | RAB9A (0.60) | KDM4EMAPTKMT2AL3MBTL1CYP2C19 | |
| SCHEMBL5060747 | 0.71 | HCAR2 (0.65) | KDM4EMAPTKMT2AL3MBTL1MAPK1 | |
| SCHEMBL9157751 | 0.71 | MAPT (0.59) | KDM4EMAPTKMT2AL3MBTL1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147170-A2 | DRUG COMBINATIONS COMPRISING A DGAT INHIBITOR AND A PPAR-AGONIST | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-10 | — | — | WO | disclosed |