Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9158027 | 0.83 | CA12 (0.62) | MAPTAKR1C3LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10486401 | 0.83 | L3MBTL1 (0.70) | MAPTAKR1C3LMNASMN1; SMN2TP53 | |
| SCHEMBL26758591 | 0.82 | MAPT (0.84) | MAPTLMNASMN1; SMN2TP53POLB | |
| SCHEMBL6134787 | 0.80 | ALDH1A1 (0.56) | MAPTLMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL630856 | 0.79 | AKR1C3 (0.65) | MAPTAKR1C3LMNASMN1; SMN2POLB | |
| SCHEMBL82046 | 0.79 | GFER (0.71) | MAPTAKR1C3LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10401922 | 0.78 | MAPT (0.51) | MAPTAKR1C3LMNASMN1; SMN2TP53 | |
| SCHEMBL14220699 | 0.78 | L3MBTL1 (0.73) | MAPTAKR1C3LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13257760 | 0.77 | AKR1C3 (0.63) | MAPTAKR1C3LMNASMN1; SMN2POLB | |
| SCHEMBL9410734 | 0.77 | AKR1C3 (0.63) | MAPTAKR1C3LMNASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343708-B1 | Avermectin derivatives | MERCK & CO INC (US) | 1995-02-15 | — | — | EP | claimed |
| EP-0343708-A2 | Avermectin derivatives | MERCK & CO. INC. (US) | 1989-11-29 | — | — | EP | claimed |
| US-4873224-A | Avermectin derivatives | MERCK & CO., INC. (US) | 1989-10-10 | — | — | US | claimed |
| EP-0343708-B1 | Avermectin derivatives | MERCK & CO INC (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0343708-A2 | Avermectin derivatives | MERCK & CO. INC. (US) | 1989-11-29 | — | — | EP | disclosed |
| US-4873224-A | Avermectin derivatives | MERCK & CO., INC. (US) | 1989-10-10 | — | — | US | disclosed |