Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PLK1 | P53350 | 8/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250247 | 0.83 | HDAC6 (0.80) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL13667788 | 0.81 | HDAC8 (0.57) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL15893678 | 0.79 | HDAC8 (0.55) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL13761357 | 0.78 | CA12 (0.47) | HDAC6HPGDPLK1ALDH1A1HSD17B10 | |
| SCHEMBL301051 | 0.78 | MAPT (0.62) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL6887653 | 0.78 | MAPT (0.62) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL2760489 | 0.78 | TP53 (0.56) | SMN1; SMN2ALDH1A1HSD17B10KMT2A | |
| SCHEMBL20040449 | 0.78 | HDAC8 (0.53) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL16198923 | 0.77 | HDAC6 (0.70) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL14115137 | 0.77 | HDAC6 (0.70) | HDAC8HDAC6HDAC2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114262321-B | Bistable light-regulated small molecular protein degradation agent, preparation method and application | 中国药科大学 | 2024-08-09 | — | — | CN | disclosed |
| CN-114262321-A | Bistable light-regulated small-molecule protein degradation agent, preparation method and application | 中国药科大学 | 2022-04-01 | — | — | CN | disclosed |
| US-7625917-B2 | S-o-(phenylaminocarbonyl)phenyl-substituted, especially with a quaternary onium group; enhanced antiviral activity and better reactivity with zinc finger moieties, particularly, the zinc finger on HIV-1's NCp7 nucleocapsid protein | TURPIN JAMES A | 2009-12-01 | — | — | US | disclosed |