Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.62 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516456 | 0.89 | ALDH1A1 (0.73) | PABPC1ADORA2AALDH1A1CYP2C19TSHR | |
| Ammonia Solution, Strong SCHEMBL8547494 | 0.87 | ALDH1A1 (0.71) | PABPC1ADORA2AALDH1A1CYP2C19TSHR | |
| SCHEMBL13609274 | 0.86 | ADORA2A (0.67) | PABPC1ADORA2AMAPK1NCOA1NCOA3 | |
| SCHEMBL22521838 | 0.84 | RXFP1 (0.65) | PABPC1ADORA2AMAPK1NCOA1NCOA3 | |
| SCHEMBL13609275 | 0.81 | RXFP1 (0.60) | PABPC1ADORA2AALDH1A1CYP2C19TSHR | |
| SCHEMBL4613444 | 0.79 | RXFP1 (0.67) | PABPC1ADORA2AALDH1A1CYP2C19TSHR | |
| SCHEMBL25090500 | 0.78 | ADORA2A (0.65) | PABPC1ADORA2AADORA2B | |
| SCHEMBL16029332 | 0.78 | ALDH1A1 (0.71) | PABPC1ADORA2AALDH1A1CYP2C19TSHR | |
| SCHEMBL10350972 | 0.77 | RXFP1 (0.65) | PABPC1ADORA2AALDH1A1CYP2C19TSHR | |
| SCHEMBL10688449 | 0.76 | KDM4E (0.74) | PABPC1ADORA2AALDH1A1CYP3A4ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871751-B2 | Compositions and methods relating to nuclear hormone and steroid hormone receptors including inhibitors of estrogen receptor alpha-mediated gene expression and inhibition of breast cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-10-28 | — | — | US | disclosed |
| US-8871751-B2 | Compositions and methods relating to nuclear hormone and steroid hormone receptors including inhibitors of estrogen receptor alpha-mediated gene expression and inhibition of breast cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090291972-A1 | Compositions and Methods Relating to Nuclear Hormone and Steroid Hormone Receptors Including Inhibitors of Estrogen Receptor Alpha-mediated Gene Expression and Inhibition of Breast Cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-11-26 | — | — | US | disclosed |
| US-20090291972-A1 | Compositions and Methods Relating to Nuclear Hormone and Steroid Hormone Receptors Including Inhibitors of Estrogen Receptor Alpha-mediated Gene Expression and Inhibition of Breast Cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291972-A1 | Compositions and Methods Relating to Nuclear Hormone and Steroid Hormone Receptors Including Inhibitors of Estrogen Receptor Alpha-mediated Gene Expression and Inhibition of Breast Cancer | PGR, ESR1, CYP19A1 | PABPC1 1816/4885ADORA2A 566/4885MAPK1 3719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.