Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823579 | 0.79 | CYP3A4 (0.40) | MAOAMAOBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1828659 | 0.76 | GRIA1 (0.39) | MAOAMAOBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12676114 | 0.76 | ALDH1A1 (0.44) | MAOAMAOBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12676199 | 0.73 | USP30 (0.40) | CYP3A4CYP2D6CYP2C9CYP19A1 | |
| SCHEMBL9892497 | 0.69 | KDM4E (0.38) | CYP3A4CYP2D6CYP2C9PDE3BPDE3A | |
| SCHEMBL27951163 | 0.65 | CYP3A4 (0.46) | MAOAMAOBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1238675 | 0.65 | DRD4 (0.38) | CYP3A4CYP2D6CYP2C9CYP11B2CYP11B1 | |
| SCHEMBL2825270 | 0.65 | CYP19A1 (0.35) | MAOAMAOBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5163435 | 0.64 | MAOA (0.58) | MAOAMAOBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12990596 | 0.62 | KDM4E (0.47) | CYP3A4CYP2D6ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152868-A1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW MAO INHIBITORS AND IMIDAZOLINE RECEPTOR LIGANDS | ROTTAPHARM S.P.A. (IT) | 2009-12-23 | — | — | WO | disclosed |