Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 5/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 10/20 | 0.47 |
| ▸ | TMPRSS15 | P98073 | 4/20 | 0.47 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1834431 | 0.85 | NAALAD2 (0.56) | NAALAD2FOLH1RIMKLAGAA | |
| SCHEMBL5259353 | 0.85 | NAALAD2 (0.56) | NAALAD2FOLH1RIMKLAGAA | |
| SCHEMBL4654148 | 0.84 | FOLH1 (0.47) | NAALAD2FOLH1TMPRSS15RIMKLAPRSS1 | |
| SCHEMBL4654152 | 0.84 | FOLH1 (0.47) | NAALAD2FOLH1TMPRSS15RIMKLAPRSS1 | |
| SCHEMBL13417040 | 0.81 | NAALAD2 (0.43) | NAALAD2FOLH1TMPRSS15RIMKLAPRSS1 | |
| SCHEMBL18476464 | 0.81 | FOLH1 (0.52) | NAALAD2FOLH1 | |
| SCHEMBL4652873 | 0.81 | GAA (0.42) | NAALAD2FOLH1TMPRSS15RIMKLAGAA | |
| SCHEMBL4653834 | 0.81 | GAA (0.42) | NAALAD2FOLH1TMPRSS15RIMKLAGAA | |
| SCHEMBL26915268 | 0.80 | FOLH1 (0.50) | NAALAD2FOLH1RIMKLAGAA | |
| SCHEMBL8477195 | 0.80 | FOLH1 (0.50) | NAALAD2FOLH1RIMKLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534670-B1 | ENZYME ACTIVATED SELF-IMMOLATIVE N-SUBSTITUTED NITROGEN MUSTARD PRODRUGS | CANCER REC TECH LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-7235585-B2 | Enzyme activated self-immolative n-substituted nitrogen mustard prodrugs | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-06-26 | — | — | US | disclosed |
| US-7235585-B2 | Enzyme activated self-immolative n-substituted nitrogen mustard prodrugs | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-06-26 | — | — | US | disclosed |