Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 5/20 | 0.47 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.47 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654148 | 1.00 | FOLH1 (0.47) | FOLH1NAALAD2RIMKLATMPRSS15CA2 | |
| SCHEMBL5259353 | 0.87 | NAALAD2 (0.56) | FOLH1NAALAD2RIMKLAGAA | |
| SCHEMBL1834431 | 0.87 | NAALAD2 (0.56) | FOLH1NAALAD2RIMKLAGAA | |
| SCHEMBL13610482 | 0.84 | NAALAD2 (0.49) | FOLH1NAALAD2RIMKLATMPRSS15GAA | |
| SCHEMBL8477195 | 0.81 | FOLH1 (0.50) | FOLH1NAALAD2RIMKLACA2CA1 | |
| SCHEMBL26915268 | 0.81 | FOLH1 (0.50) | FOLH1NAALAD2RIMKLACA2CA1 | |
| SCHEMBL4653834 | 0.79 | GAA (0.42) | FOLH1NAALAD2RIMKLATMPRSS15CA2 | |
| SCHEMBL4652873 | 0.79 | GAA (0.42) | FOLH1NAALAD2RIMKLATMPRSS15CA2 | |
| SCHEMBL5262634 | 0.78 | KMT2A (0.57) | NAALAD2TMPRSS15CA2CA1GAA | |
| SCHEMBL5262631 | 0.78 | KMT2A (0.57) | NAALAD2TMPRSS15CA2CA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355876-B1 | METHODS OF CHEMICAL SYNTHESIS OF PHENOLIC NITROGEN MUSTARD PRODRUGS | CANCER RES INST ROYAL (GB) | 2008-11-05 | — | — | EP | disclosed |
| US-6916949-B2 | Methods of chemical systhesis of phenolic nitrogen mustard prodrugs | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-07-12 | — | — | US | disclosed |
| US-20040087813-A1 | Methods of chemical systhesis of phenolic nitrogen mustard prodrugs | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2004-05-06 | — | — | US | disclosed |
| EP-1355876-A1 | METHODS OF CHEMICAL SYNTHESIS OF PHENOLIC NITROGEN MUSTARD PRODRUGS | Cancer Research Technology Limited (GB) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002060862-A1 | METHODS OF CHEMICAL SYNTHESIS OF PHENOLIC NITROGEN MUSTARD PRODRUGS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2002-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087813-A1 | Methods of chemical systhesis of phenolic nitrogen mustard prodrugs | GGH, GLUL, GSS | FOLH1 150/4885NAALAD2 331/4885RIMKLA 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.