Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | GNRHR | P30968 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 4/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376208 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1PKMHPGDHSD17B10 | |
| SCHEMBL4379494 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1PKMHPGDHSD17B10 | |
| SCHEMBL4380254 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1PKMHPGDHSD17B10 | |
| SCHEMBL14547795 | 0.78 | MAPK14 (0.58) | KDM4EALDH1A1PKMMAPK14POLB | |
| SCHEMBL4377634 | 0.75 | MAPK14 (0.52) | KDM4EALDH1A1PKMHPGDHSD17B10 | |
| SCHEMBL3519568 | 0.73 | MEN1 (0.52) | KDM4EALDH1A1PKMHPGDHSD17B10 | |
| SCHEMBL3527401 | 0.72 | MEN1 (0.54) | KDM4EALDH1A1PKMHPGDHSD17B10 | |
| SCHEMBL13635178 | 0.71 | MAPK14 (0.56) | MAPK14 | |
| SCHEMBL4382351 | 0.71 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTPOLBLMNA | |
| SCHEMBL4490349 | 0.70 | MAPK14 (0.64) | KDM4EALDH1A1PKMMAPK14POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629363-B2 | antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |