Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.38 |
| ▸ | SMO | Q99835 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4277807 | 0.90 | NR3C1 (0.49) | NR3C1P2RY12SMO | |
| SCHEMBL13611162 | 0.88 | POLB (0.43) | NR3C1SMO | |
| SCHEMBL13611160 | 0.82 | NR3C1 (0.42) | NR3C1P2RY12SMO | |
| SCHEMBL4277316 | 0.80 | NR3C1 (0.51) | NR3C1P2RY12SMOCYP11B1CYP11B2 | |
| SCHEMBL13611164 | 0.79 | NR3C1 (0.45) | NR3C1SMOCYP11B1CYP11B2 | |
| SCHEMBL4281571 | 0.78 | NR3C1 (0.50) | NR3C1SMO | |
| SCHEMBL4275989 | 0.77 | NR3C1 (0.51) | NR3C1P2RY12SMOCYP11B1CYP11B2 | |
| SCHEMBL4275271 | 0.75 | NR3C1 (0.56) | NR3C1SMOCYP11B1CYP11B2 | |
| SCHEMBL27724526 | 0.74 | NR3C1 (0.47) | NR3C1SMOCYP11B1CYP11B2 | |
| SCHEMBL4280121 | 0.74 | NR3C1 (0.54) | NR3C1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622594-B2 | Glucocortioid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |