Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603626 | 1.00 | SRD5A2 (0.44) | SRD5A2ARSRD5A1AKR1B10AKR1B1 | |
| SCHEMBL7622722 | 0.85 | SRD5A2 (0.61) | SRD5A2ARSRD5A1 | |
| SCHEMBL13611192 | 0.82 | SRD5A1 (0.40) | SRD5A2SRD5A1 | |
| SCHEMBL13603641 | 0.82 | SRD5A1 (0.40) | SRD5A2SRD5A1 | |
| SCHEMBL8381867 | 0.79 | SRD5A2 (0.46) | SRD5A2ARSRD5A1 | |
| SCHEMBL13611185 | 0.78 | SRD5A2 (0.49) | SRD5A2ARSRD5A1 | |
| SCHEMBL13603625 | 0.78 | SRD5A2 (0.49) | SRD5A2ARSRD5A1 | |
| SCHEMBL8536963 | 0.78 | AKR1B10 (0.61) | ARAKR1B10AKR1B1GPBAR1 | |
| SCHEMBL8795547 | 0.77 | SRD5A1 (0.56) | SRD5A2SRD5A1 | |
| SCHEMBL13611190 | 0.76 | SRD5A2 (0.50) | SRD5A2ARSRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625919-B2 | 4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |